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CAS RN: 167221-71-8 | 产品编码: C3503
Clevidipine
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纯度/分析方法: >98.0%(HPLC)
别名：
- 氯维地平
- 4-(2,3-二氯苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二甲酸3-[(丁酰氧基)甲基]5-甲酯
- 3-[(Butyryloxy)methyl] 5-Methyl 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Aicd 3-[(Butyryloxy)methyl] 5-Methyl Ester
产品文档：
| 产品编码 | C3503 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__1H__2__3Cl__2NO__6 = 456.32 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 167221-71-8 |
| Reaxys-RN | 8450029 |
| PubChem物质ID | 354335546 |
| Merck Index (14) | 2352 |
| MDL编号 | MFCD00940070 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 96.0 % |
| Melting point | 141.0 to 145.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 143 °C |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 0.1 g/l |
GHS
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Clevidipine: An Ultrashort-Acting 1,4-Dihydropyridine L-Type Calcium Channel Antagonist
Clevidipine is an ultrashort-acting L-type calcium channel antagonist with selectivity for arteriolar vasodilatation. L-type calcium channels mediate the influx of calcium during depolarization in arterial smooth muscle. Clevidipine particularly induce a relaxation of the muscle in arterial bed, and reduces arterial blood pressure by decreasing systemic vascular resistance directly. On the other hand, clevidipine does not reduce cardiac filling pressure, confirming lack of effects on the venous vessels. Clevidipine is a 1,4-dihydropyridine calcium channel antagonist, structurally related to felodipine [F0814]. (The product is for research purpose only.)
References
- In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolized by esterases, in different animal species and man
- Pharmacokinetics of new calcium channel antagonist clevidipine in the rat, rabbit, and dog and pharmacokinetic/pharmacodynamic relationship in anesthetized dogs
- Clevidipine. A review of its use in the management of acute hypertension
- Determination of an ultrashort-acting antihypertensive dihydropyridine, clevidipine, in blood using capillary gas chromatography-mass spectrometry and of the primary metabolite using liquid chromatography and fluorescence detection
- Enantioselective pharmacokinetics of the enantiomers of clevidipine following intravenous infusion of the racemate in essential hypertensive patients
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