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CAS RN: 14892-97-8 | 产品编码: C3577
SCR7 Pyrazine
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| 产品编码 | C3577 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__1__8H__1__2N__4OS = 332.38 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
10MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 14892-97-8 |
| Reaxys-RN | 306520 |
| PubChem物质ID | 468591173 |
| MDL编号 | MFCD02167478 |
技术规格
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 207.0 to 211.0 °C |
| Elemental analysis(Nitrogen) | 16.00 to 17.50 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 209 °C |
| 最大吸收波长 | 380 nm |
GHS
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
CRISPR Genome Editing
SCR7 Pyrazine enhances CRISPR-mediated homology-directed repair (HDR) efficiency.
References
- Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing of HSV-1 virus in human cells
应用
DNA Ligase Inhibitor: SCR7 Pyrazine
References
- CRISPR-Cas systems for editing, regulating and targeting genomes
- Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
- Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
- An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression
- SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV
- Synthesis and structure determination of SCR7, a DNA ligase inhibitor
- Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner
- Water-soluble version of SCR7-pyrazine inhibits DNA repair and abrogates tumor cell proliferation
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