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CAS RN: 35607-66-0 | 产品编码: C3598
Cefoxitin
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纯度/分析方法: >98.0%(HPLC)
别名：
- 头孢西丁
- (6R,7S)-3-[(氨基甲酰氧基)甲基]-7-甲氧基-8-氧代-7-[2-(噻吩-2-基)乙酰氨基]-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸
- (6R,7S)-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
产品文档：
补充产品信息:
This product has not been tested for potency and is guaranteed for chemical purity.
| 产品编码 | C3598 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__6H__1__7N__3O__7S__2 = 427.45 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 35607-66-0 |
| Reaxys-RN | 4216947 |
| PubChem物质ID | 468591185 |
| Merck Index (14) | 1936 |
| MDL编号 | MFCD00072014 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
物性（参考值）
| 熔点 | 127 °C(dec.) |
| 溶解性（可溶于） | 二甲基甲酰胺 |
| 溶解性（不溶于） | 乙醚, 氯仿 |
GHS
相关法规
| RTECS# | XI0386500 |
运输信息
| HS编码* | 2941.90-000 |
应用
Cefoxitin: A Second Generation Cephem Antibiotic against beta-Lactamase
Cefoxitin and its sodium salt [C3602] are semi-synthetic antibiotic that are derived from cephamycin C which is produced by Streptomyces lactamdurans. Cefoxitins have bactericidal activity against a wide range of Gram-negative and Gram-positive bacteria including aerobes and anaerobes.1-3) Cefoxitins are second generation cephem antibiotics which act by inhibition bacterial cell wall synthesis. Due to the presence of a 7-α methoxy group in the β-lactam ring, cefoxitins exhibit a high degree of stability in the presence of beta-lactamases. In addition, cefoxitin disk diffusion method has been used for the tests for routine detection of all classes of MRSA.4,5)
References
- 1) Cefoxitin, a semi-synthetic cephamycin: a microbiological overview (a review)
- 2) Cefoxitin and cephamycins: microbiological studies (a review)
- 3) Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use
- 4) Evaluation of three techniques for detection of low-level methicillin-resistant Staphylococcus aureus (MRSA): a disk diffusion method with cefoxitin and moxalactam, the Vitek 2 system, and the MRSA-screen latex agglutination test
- 5) Results of disk diffusion testing with cefoxitin correlate with presence of mecA in Staphylococcus spp.
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