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CAS RN: 160098-96-4 | 产品编码: C3599
SCH 58261
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技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 221.0 to 225.0 °C |
| Elemental analysis(Nitrogen) | 27.00 to 29.80 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 223 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | UR0809279 |
运输信息
| HS编码* | 2934.99-000 |
应用
SCH 58261: A Competitive and Selective Antagonist of the Adenosine A2A Receptor
SCH 58261 is a competitive and selective antagonist of the adenosine A2A receptor (A2AR), which is one of the four subtypes of adenosine receptors (A1R, A2AR, A2BR, and A3R). SCH 58261 is selective for the A2AR, displaying an A1/A2A selectivity ratio of 50 to 100-fold in rat and bovine brain, respectively, and does not interact with A2BR or A3R. It has been reported that SCH 58261 has a potential for treatment of brain damage produced by Parkinson's disease or stroke. (The product is for research purpose only.)
References
- The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist
- Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischemia in rats
- SCH 58261: a selective A2A adenosine receptor antagonist (a review)
- Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors
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