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CAS RN: 33564-30-6 | 产品编码: C3602
Cefoxitin Sodium
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 头孢西丁钠
- (6R,7S)-3-[(氨基甲酰氧基)甲基]-7-甲氧基-8-氧代-7-[2-(噻吩-2-基)乙酰胺基]-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸钠
- Sodium (6R,7S)-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
产品文档：
补充产品信息:
This product has not been tested for potency and is guaranteed for chemical purity.
| 产品编码 | C3602 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__6H__1__6N__3NaO__7S__2 = 449.43 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 33564-30-6 |
| Reaxys-RN | 4104290 |
| PubChem物质ID | 468591188 |
| Merck Index (14) | 1936 |
| MDL编号 | MFCD00079042 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +202 to +210 deg(C=1, MeOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 204 °C |
| 比旋光度 [α]D | 209° (C=1,MeOH) |
| 最大吸收波长 | 260 nm (H__2O) |
| 溶解性（可溶于） | 甲醇 |
| 溶解性（不溶于） | 脂肪族烃 |
GHS
相关法规
| RTECS# | XI0330500 |
运输信息
| HS编码* | 2941.90-000 |
应用
Cefoxitin Sodium: A Second Generation Cephem Antibiotic against beta-Lactamase
Cefoxitin sodium and its free acid [C3598] are semi-synthetic antibiotic that are derived from cephamycin C which is produced by Streptomyces lactamdurans. Cefoxitins have bactericidal activity against a wide range of Gram-negative and Gram-positive bacteria including aerobes and anaerobes.1,2) Cefoxitins are second generation cephem antibiotics which act by inhibition bacterial cell wall synthesis. Due to the presence of a 7-α methoxy group in the β-lactam ring, cefoxitins exhibit a high degree of stability in the presence of beta-lactamases.1,3)
References
- 1) Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use
- 2) Bioavailability and pharmacokinetics of cefoxitin sodium (a review)
- 3) AmpC β-Lactamases (a review)
- 4) Cefoxitin, Sodium (A Review on the Properties, Synthesis, Stability, Metabolism, and Methods of Determination of Cefoxitin Sodium)
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