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CAS RN: 15663-27-1 | 产品编码: D3371
cis-Diammineplatinum(II) Dichloride
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| 产品编码 | D3371 |
| 分子式/分子量 | H__6Cl__2N__2Pt = 300.05 |
| 外观与形状（20°C） | 固体 |
储存温度 
|
室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (分解) |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 15663-27-1 |
| PubChem物质ID | 87558796 |
| Merck Index (14) | 2317 |
技术规格
| Appearance | Light orange to Yellow to Green powder to crystal |
| Elemental analysis(Nitrogen) | 8.90 to 9.80 % |
物性（参考值）
| 熔点 | 270 °C |
| 在水中的溶解度 | 2,530 mg/l 25 °C |
| 溶解性（可溶于） | 二甲基甲酰胺 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | TP2450000 |
运输信息
| UN编号 | UN3288 |
| 类别 | 6.1 |
| 包装类别 | II |
| HS编码* | 2843.90-000 |
应用
Quorum sensing inhibitor
Reference
- The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors
应用
Platinum Coordination Complexes as Antitumor Agents
The development of platinum coordination complexes as antitumor agents began in the 1960s, and the highest antitumor activity was exhibited by cisplatin, approved by FDA in 1978. Improved versions carboplatin [C2043] and oxaliplatin [O0372] were developed to avoid the serious side effects and the problem with resistance associated with the use of cisplatin.1-5)
The platinum complexes diffuse to the tumor cell, where they undergo hydrolysis displacement of their one chloride or carboxylate group leading to a platinum cation. The resulting cation coordinates to the guanine N7-position of DNA give a coordination cation. Then, intrastrand cross-linking occurs to anther guanine via further hydrolysis displacement of the remaining chloride or carboxylate. The forming [Pt(NH2R)2]2+ ― DNA complex distort the DNA helix (Fig. 1 and 2)6). Thus, DNA duplication is hindered, which ultimately triggers tumor cell apoptosis.3)
The platinum complexes diffuse to the tumor cell, where they undergo hydrolysis displacement of their one chloride or carboxylate group leading to a platinum cation. The resulting cation coordinates to the guanine N7-position of DNA give a coordination cation. Then, intrastrand cross-linking occurs to anther guanine via further hydrolysis displacement of the remaining chloride or carboxylate. The forming [Pt(NH2R)2]2+ ― DNA complex distort the DNA helix (Fig. 1 and 2)6). Thus, DNA duplication is hindered, which ultimately triggers tumor cell apoptosis.3)
References
- 1)G. Mathe, Y. Kidani, M. Segiguchi, M. Eriguchi, G. Fredj, G. Peytavin, J. L. Misset, S. Brienza, F. de Vassals, E. Chenu, C. Bourut, Biomed. Pharmacother. 1989, 43, 237.
- 2)L. R. Kelland, S. Y. Sharp, C. F. O’Neill, F. I. Raynaud, P. J. Beale, I. R. Judson, J. Inorg. Biochem. 1999, 77, 111.
- 3)D. Wang, S. J. Lippard, Nat. Rev. Drug Discov. 2005, 4, 307.
- 4)S. Trzaska, Chem. Eng. News 2005, 83, 3.
- 5)L. P. Martin, T. C. Hamilton, R. J. Schilder, Clin. Cancer Res. 2008, 14, 1291.
- 6)A. Gelasco, S. J. Lippard, Biochemistry, 1998, 37, 9230.
应用
Reagent for renal failure model
References
- Cis-diamminedichloroplatinum (DDP) induced acute renal failure (ARF): attempts at amelioration
- S. Chopra, J. Kaufman, W. Flamenbaum, Clin. Exp. Dial. Apheresis. 1983, 7, 25.
- Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat: enzyme histochemical studies
- Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations
- T. W. Jones, S. Chopra, J. S. Kaufman, W. Flamenbaum, B. F. Trump, Lab. Invest. 1985, 52, 363.
- Protective effects of dithiocarbamates against renal toxicity of cis-diamminedichloroplatinum in rats
- Celecoxib, a selective cyclooxygenase-2 inhibitor, attenuates renal injury in a rat model of Cisplatin-induced nephrotoxicity
- Effect of fructose-1,6-bisphosphate on the nephrotoxicity induced by cisplatin in rats
- Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis
应用
Reagent for nausea or vomiting model
References
- Cisplatin-induced emesis in the Ferret: a new animal model.
- A. P. Florczyk, J. E. Schurig, W. T. Bradner, Cancer Treat Rep. 1982, 66, 1, 187-189.
- The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential.
应用
Reviews on the Biochemical Mechanisms of Action of Cisplatin
References
- Structure, recognition, and processing of cisplatin-DNA adducts
- Why does cisplatin reach guanine-N7 with competing S-donor ligands available in the cell?
- Biochemical modulation of cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance
- Cisplatin: mode of cytotoxic action and molecular basis of resistance
- Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair.
- G. Chu. J. Biol. Chem. 1994, 269, 787.
- Cellular processing of platinum anticancer drugs
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