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CAS RN: 33286-22-5 | 产品编码: D3662
(+)-cis-Diltiazem Hydrochloride
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- (+)-顺-地尔硫卓盐酸盐
- (2S,3S)-(+)-3-乙酰氧基-2,3-二氢-5-[2-(二甲基氨基)乙基]-2-(4-甲氧基苯基)-1,5-苯并硫氮杂环庚烷-4(5H)-酮盐酸盐
- (2S,3S)-(+)-3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride
产品文档：
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | 114 to 122 deg(C=1, H2O) |
物性（参考值）
| 熔点 | 210 °C |
| 比旋光度 [α]D | 118° (C=1,H2O) |
| 水溶性 | 可溶 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | DL0310000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Diltiazem: A Calcium Channel Antagonist
Diltiazem, a calcium channel antagonist, is a potent vasodilator and used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. Diltiazem is metabolized by and acts as an inhibitor of cytochrome P-450 3A (CYP3A). (The product is for research purpose only.)
References
- Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialyzed heart cells
- Diltiazem. A review of its pharmacological properties and therapeutic efficacy (a review)
- Diltiazem. A reappraisal of its pharmacological properties and therapeutic use (a review)
- Diltiazem hydrochloride (a review)
- Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation
参考文献
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