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CAS RN: 71939-50-9 | 产品编码: D3793
Dihydroartemisinin
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| 产品编码 | D3793 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__1__5H__2__4O__5 = 284.35 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 71939-50-9 |
| Reaxys-RN | 5813803 |
| PubChem物质ID | 87561556 |
| SDBS (AIST Spectral DB) | 52709 |
| Merck Index (14) | 817 |
| MDL编号 | MFCD00274495 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 %(Anomeric total) |
物性（参考值）
| 熔点 | 153 °C(dec.) |
GHS
相关法规
| RTECS# | KD4165550 |
运输信息
| HS编码* | 2932.99-000 |
应用
Dihydroartemisinin: An Active Metabolite of Antimalaria Artesunate
Dihydroartemisinin is an active metabolite of artesunate [A2191] which is a semi-synthetic derivative of artemisinin [A2118]. Dihydroartemisinin and its analogs have high efficacy against Plasmodium falciparum in the blood stages of the disease. The exact mechanism of action is still not clear, while the endoperoxide (O-O) subunit of the trioxane ring is critical for antimalarial activity. Several lines of evidence indicate that the O-O bond is easily broken by Fe2+, generating a number of reactive radicals oxidatively damage parasite. In clinical, dihydroartemisinin is often used as a combination agent with a partner agent which has a long half-life, such as piperaquine. In addition, after 2000’s, the anti-tumor activities of dihydroartemisinin have been reported. (The product is for research purpose only.)
References
- Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration
- Efficacy and safety of dihydroartemisinin-piperaquine
- Dihydroartemisinin is an inhibitor of ovarian cancer cell growth
- Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy
- Dihydroartemisinin inactivates NF-κB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo
- Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma
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