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CAS RN: 114977-28-5 | 产品编码: D4102
Docetaxel
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| 产品编码 | D4102 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__4__3H__5__3NO__1__4 = 807.89 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 114977-28-5 |
| Reaxys-RN | 4290183 |
| PubChem物质ID | 160871242 |
| Merck Index (14) | 3397 |
| MDL编号 | MFCD00800737 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -42.0 to -45.0 deg(C=1、EtOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 188 °C(dec.) |
| 比旋光度 [α]D | -43° (C=1,EtOH) |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 乙醇, 甲醇, 二氯甲烷 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | DA4172750 |
运输信息
| HS编码* | 2932.99-000 |
应用
Docetaxel: A Microtubule Stabilizer and a Depolymerization Inhibitor
Docetaxel (taxotere, RP 56976) is an active semisynthetic analog of paclitaxel (taxol) [P1632] which is isolated from the bark of the Pacific yew, Taxus brevifolia. Docetaxel promotes tubulin assembly in microtubules and inhibits their depolymerization, leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. Docetaxel has solubility in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), but very poor solubility in water. Therefore, enhanced the solubility of docetaxel in water, some controlled-release drug delivery systems have been studied. For your reference, [B4127] is a synthetic Intermediate of the side chains of docetaxel and paclitaxel. (The product is for research purpose only.)
References
- Studies with RP 56976 (taxotere): a semisynthetic analog of taxol
- Experimental antitumor activity of Taxotere (RP 56976, NSC 628503), a taxol analog
- Taxol and taxotere: discovery, chemistry, and structure-activity relationships (a review)
- Docetaxel (a review of its activity, tolerability, and pharmacokinetics in preclinical and clinical experience)
- Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
- Sensitive liquid chromatography-mass spectrometry assay for quantitation of Docetaxel and Paclitaxel in human plasma
参考文献
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