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CAS RN: 251456-60-7 | 产品编码: D4188
4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
![4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide Chemical Structure of 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide](/medias/D4188.jpg?context=bWFzdGVyfHJvb3R8MzY4NDB8aW1hZ2UvanBlZ3xhR1V3TDJoaFl5ODRPVEl4TXpJME5URTVORFUwTDBRME1UZzRMbXB3Wnd8ZjU3NzE2MTVkYjhhMDMzYjFkMGJmZjhiNDJhOWRhMTQwOTUxNWIxMTZhOWZmMTBmYzhiZWUyYTViNDkzMWNkYg)
产品编码 | D4188 |
纯度/分析方法 ![]() |
>97.0%(HPLC) |
分子式/分子量 | C__1__6H__2__5N__3O__3 = 307.39 |
外观与形状(20°C) | 固体 |
储存温度 ![]() |
冷藏 (0-10°C) |
应避免的情况 | 加热 |
包装和容器 ![]() |
100MG-Glass Bottle with Plastic Insert (查看图片), 20MG-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 251456-60-7 |
Reaxys-RN | 8570090 |
PubChem物质ID | 160871269 |
MDL编号 | MFCD03453554 |
技术规格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 97.0 area% |
Elemental analysis(Nitrogen) | 13.20 to 13.80 % |
NMR | confirm to structure |
物性(参考值)
熔点 | 152 °C |
GHS
相关法规
运输信息
HS编码* | 2928.00-000 |
应用
M344: A Histone Deacetylase (HDAC) Inhibitor
Histone deacetylase (HDAC) inhibitors are emerging therapeutic agents with potential for disruption of critical cellular processes in cancer cells. M344 is a synthesized HDAC inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in cancer cells. (The product is for research purpose only.)
References
- Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
- Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation
- The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells
- M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells
- Histone deacetylase inhibitor M344 inhibits cell proliferation and induces apoptosis in human THP-1 leukemia cells
- Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB
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