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CAS RN: 25316-40-9 | 产品编码: D4193
Doxorubicin Hydrochloride
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| 产品编码 | D4193 |
纯度/分析方法 
|
>95.0%(HPLC) |
| 分子式/分子量 | C__2__7H__2__9NO__1__1·HCl = 579.98 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 光,加热 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 25316-40-9 |
| 相关CAS RN
|
23214-92-8 |
| Reaxys-RN | 4229251 |
| PubChem物质ID | 253660149 |
| Merck Index (14) | 3439 |
| MDL编号 | MFCD00077757 |
技术规格
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation | +240 to +270 deg(C=0.1,MeOH) |
物性（参考值）
| 比旋光度 [α]D | 248° (C=0.1,MeOH) |
| 最大吸收波长 | 497 nm (H__2O) |
| 水溶性 | 可溶 |
| 溶解性（可溶于） | 四氢呋喃, 甲醇 |
| 溶解性（不溶于） | 氯仿, 苯, 丙酮, 乙醚 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. H351 : Suspected of causing cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | QI9295900 |
运输信息
| HS编码* | 2941.90-000 |
应用
Mitochondria research
Reference
- Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells
应用
Adeno-associated virus vector transduction enhancer
Doxorubicin increases transduction by adeno-associated virus (AAV) vectors.1-3)
References
- 1) Doxorubicin augments rAAV-2 transduction in rat neuronal cells
- 2) Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway
- 3) Distinct classes of proteasome-modulating agents cooperatively augment recombinant adeno-associated virus type 2 and type 5-mediated transduction from the apical surfaces of human airway epithelia
应用
Reagent for nephritis (glomerulonephritis) model
References
- Adriamycin-induced nephrotic syndrome in rats: sequence of pathologic events
- T. Bertani, A. Poggi, R. Pozzoni, F. Delaini, G. Sacchi, Y. Thoua, G. Mecca, G. Remuzzi, M. B. Donati, Lab. Invest. 1982, 46, 16.
- Adriamycin-induced chronic proteinuria: a structural and functional study
- M. P. O'Donnell, L. Michels, B. Kasiske, L. Raij, W. F. Keane, J. Lab. Clin. Med. 1985 106, 62.
- Effect of dietary protein restriction on renal purines and purine-metabolizing enzymes in adriamycin nephrosis in rats: a mechanism for protection against acute proteinuria involving xanthine oxidase inhibition
- G. M. Ghiggeri, F. Ginevri, G. Cercignani, R. Oleggini, A. Garberi, G. Candiano, P. Altieri, R. Gusmano, Clin. Sci. (Lond). 1990, 79, 647.
- Effect of enalapril on adriamycin-induced nephrosis
- Erlotinib preserves renal function and prevents salt retention in doxorubicin treated nephrotic rats
- Protective effects of sinomenine against doxorubicin-induced nephrosis in rats
应用
Reagent for cardiomyopathy model
References
- Adriamycin-induced cardiac damage in the mouse: a small-animal model of cardiotoxicity
- S. H. Rosenoff, H. M. Olson, D. M. Young, F. Bostick, R. C. Young, J. Natl. Cancer Inst. 1975, 55, 191.
- Experimental animal models of adriamycin cardiotoxicity
- J. H. Doroshow, G. Y. Locker, C. E. Myers, Cancer Treat. Rep. 1979, 63, 855.
- Adriamycin-induced cardiomyopathy. A rat model
- A. Czarnecki, A. Hinek, D. Sołtysiak-Pawluczuk, Pol. J. Pharmacol. Pharm. 1986, 38, 171.
- Chronic doxorubicin induced cardiomyopathy in rabbits: mechanical, intracellular action potential, and beta adrenergic characteristics of the failing myocardium
- Serial assessment of myocardial properties using cyclic variation of integrated backscatter in an adriamycin-induced cardiomyopathy rat model
- Improvement of doxorubicin induced cardiomyopathy in rats treated with insulin-like growth factor I
- Intracoronary infusion of skeletal myoblasts improves cardiac function in doxorubicin-induced heart failure
- Doxorubicin dose for congestive heart failure modeling and the use of general ultrasound equipment for evaluation in rats Longitudinal in vivo study.
应用
Reagent for nausea or vomiting model
Reference
- The antiemetic effect of a novel tropisetron patch in anticancer agents-induced kaolin pica model using rats
应用
Reviews on an Anti-tumor Anthracycline Antibiotic, Doxorubicin
Doxorubicin is a widely used anti-tumor anthracycline antibiotic which exhibits good activity against a wide range of tumors. Doxorubicin interacts with DNA by intercalation and inhibition of DNA replication.
References
- A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics Adriamycin and daunorubicin
- Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
- The Power and Potential of Doxorubicin-DNA Adducts
- Pharmacokinetics of pegylated liposomal doxorubicin: review of animal and human studies
- Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
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