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CAS RN: 136434-34-9 | 产品编码: D4223
Duloxetine Hydrochloride
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| 产品编码 | D4223 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__8H__1__9NOS·HCl = 333.87 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 136434-34-9 |
| 相关CAS RN
|
116539-59-4 |
| Reaxys-RN | 8168890 |
| PubChem物质ID | 160871378 |
| Merck Index (14) | 3465 |
| MDL编号 | MFCD06407958 |
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 161.0 to 165.0 °C |
| Specific rotation [a]20/D | +120 to +124 deg(C=1, MeOH) |
物性（参考值）
| 熔点 | 164 °C |
| 比旋光度 [α]D | 122° (C=1,MeOH) |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | XN0258000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Duloxetine Hydrochloride: A Selective Serotonin and Norepinephrine Reuptake Inhibitor (SNRI)
Serotonin (5-hydroxytryptamine [S0370] or 5-HT) and norepinephrine [A0906] are implicated in modulating descending inhibitory pain pathways in the central nervous system. Duloxetine hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and lacks affinity for monoamine receptors within the central nervous system. Duloxetine hydrochloride is mainly used for the treatment of depression. Although the exact mechanisms of the antidepressant are unknown, these actions are believed to be related to its potentiation of serotonergic and norepinephrinergic activity in the central nervous system.
There are other SNRIs as; (S)-citalopram oxalate [E0958], citalopram hydrobromide [C2370], fluoxetine hydrochloride [F0750], fluvoxamine maleate [F0858], milnacipran hydrochloride [M2133], paroxetine hydrochloride [P1977], sertraline hydrochloride [S0507] and venlafaxine hydrochloride [V0110]. (The product is for research purpose only.)
There are other SNRIs as; (S)-citalopram oxalate [E0958], citalopram hydrobromide [C2370], fluoxetine hydrochloride [F0750], fluvoxamine maleate [F0858], milnacipran hydrochloride [M2133], paroxetine hydrochloride [P1977], sertraline hydrochloride [S0507] and venlafaxine hydrochloride [V0110]. (The product is for research purpose only.)
References
- Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat
- Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats
- Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters in vitro and in vivo, Human Serotonin Receptor Subtypes, and Other Neuronal Receptors
- The dual transporter inhibitor duloxetine: A review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression (a review)
- Reliable HPLC method for therapeutic drug monitoring of frequently prescribed tricyclic and nontricyclic antidepressants
- HPLC analysis of the novel antidepressant duloxetine in human plasma after an original solid-phase extraction procedure
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