Maximum quantity allowed is 999
请选择数量
CAS RN: 24584-09-6 | 产品编码: D4227
Dexrazoxane
×
![]()
×
| 产品编码 | D4227 |
纯度/分析方法 
|
>98.0%(T) |
| 分子式/分子量 | C__1__1H__1__6N__4O__4 = 268.27 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 24584-09-6 |
| Reaxys-RN | 6658412 |
| PubChem物质ID | 160871504 |
| Merck Index (14) | 8123 |
| MDL编号 | MFCD00866449 |
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 193.0 to 197.0 °C |
| Specific rotation [a]20/D | +10.0 to +13.0 deg(C=5、DMF) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 195 °C |
| 比旋光度 [α]D | 11° (C=5,DMF) |
| 溶解性（可溶于） | 二甲基甲酰胺 |
| 溶解性（微溶于） | 乙醇, 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | TL6390000 |
运输信息
| HS编码* | 2933.59-000 |
应用
Studies on the Topoisomerase II Inhibitory Effects of Dexrazoxane
References
- Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(±)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and ICRF-159 (Razoxane)
- G. J. Gorbsky, Cancer Res. 1994, 54, 1042.
- Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle
- A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines
- A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane)
- Topoisomerase IIbeta-Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane
应用
Studis of Cardiotoxicity Reduction
References
- Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane
- Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines
- B. B. Hasinoff, K. Hellmann, E. H. Herman, V. J. Ferrans, Curr. Med. Chem. 1998, 5, 1.
PubMed Literature
技术文章
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
化学品安全说明书(SDS)
请选择语言。
如需更多帮助，请联系我 们。
技术规格
CoA及其他文档
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
示例 CoA
可下载CoA示例。注：该示例不一定是最新批次的CoA。
目前没有该产品的 CoA 示例。
分析图谱
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
很抱歉，您搜索的分析图谱无法提供。