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CAS RN: 65928-58-7 | 产品编码: D5230
Dienogest
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纯度/分析方法: >98.0%(HPLC)
别名：
- 地诺孕素
- 17α-17-羟基-3-氧代-19-去甲孕甾-4,9-二烯-21-腈
- 17-羟基-3-氧代-19-去甲孕甾-4,9-二烯-21-腈
- 17-氰甲基-17-羟基-雌-4,9-二烯-3-酮
- 17α-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
- 17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
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产品文档：
| 产品编码 | D5230 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__0H__2__5NO__2 = 311.43 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
250MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 65928-58-7 |
| Reaxys-RN | 5763925 |
| PubChem物质ID | 354335037 |
| Merck Index (14) | 3106 |
| MDL编号 | MFCD00868356 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 213.0 to 217.0 °C |
| Specific rotation [a]20/D | -315 to -325 deg(C=1, CH2Cl2) |
物性（参考值）
| 熔点 | 215 °C |
| 比旋光度 [α]D | -307° (C=1,CHCl3) |
| 水溶性 | 不溶 |
| 溶解性（微溶于） | 甲醇, 丙酮 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | RC8899500 |
运输信息
| HS编码* | 2937.23-000 |
应用
Dienogest: A Selective Progesterone Receptor Agonist
Dienogest, a synthetic nortestosterone [N0449] derivative, is a selective progesterone receptor agonist. Although dinogest binds to the progesterone receptor of the human uterus with only 10% of the relative affinity of progesterone, it has a strong progestogenic effect in vivo. In addition, dienogest displays moderate anti-gonadotrophic effects, but no androgenic, glucocorticoid or mineralocorticoid activity in vivo. It is reported that the agonist activity is approximately one third of that of cyproterone acetate [C2942]. Dienogest has been used in the treatment of endometriosis by reducing the endogenous production of estradiol [E0025]. (The product is for research purpose only.)
References
- Dienogest (a review)
- The inhibitory effect of dienogest, a synthetic steroid, on the growth of human endometrial stromal cells in vitro
- Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile
- Validated UPLC method for the fast and sensitive determination of steroid residues in support of cleaning validation in formulation area
- Dienogest: a review of its use in the treatment of endometriosis
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