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CAS RN: 115956-12-2 | 产品编码: D5820
Dolasetron
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技术规格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 234.0 to 238.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 236 °C |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 505 mg/l 25 °C |
GHS
相关法规
| RTECS# | NL6014644 |
运输信息
| HS编码* | 2933.99-000 |
应用
Dolasetron: A Selective Serotonin Subtype 3 (5-HT3) Receptor Antagonist
Dolasetron is the free base of dolasetron mesylate [D5481] which is a selective serotonin subtype 3 (5-HT3) receptor antagonist. It is rapidly converted in vivo to its active major metabolite, hydrodolasetron, which appears to be largely responsible for its pharmacological activity. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, selective 5-HT3 receptor antagonists, dolasetron, granisetron [G0401], ondansetron [O0407] and tropisetron [T2743] are used for the prevention of chemotherapy-induced nausea and vomiting, but they have been reported to be associated with QTc prolongation. (The product is for research purpose only.)
References
- Dolasetron: a review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery (a review)
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