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CAS RN: 22494-42-4 | 产品编码: D5875
Diflunisal
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技术规格
| Appearance | White to Almost white powder to crystaline |
| Purity(GC) | min. 98.0 % |
| Melting point | 211.0 to 215.0 °C |
| Solubility in Methanol | almost transparency |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 215 °C |
| 最大吸收波长 | 253 nm (H__2O) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | DV2030000 |
运输信息
| HS编码* | 2918.29-000 |
应用
Diflunisal: A Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibits both COX-1 and COX-2.1) In addition, diflunisal has been reported to stabilize transthyretin (TTR) tetramers and prevents amyloid fibril formation in vitro, and diflunisal is expected to use for the treatment of amyloidosis.2,3) (The product is for research purpose only.)
References
- 1) Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis
- 2) Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis
- 3) Diflunisal for ATTR cardiac amyloidosis
- 4) Diflunisal (a review of the chemical and physical properties, synthesis, stability, methods of analysis, and pharmacology)
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