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CAS RN: 201530-41-8 | 产品编码: D5905
Deferasirox
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| 产品编码 | D5905 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__1H__1__5N__3O__4 = 373.37 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 201530-41-8 |
| Reaxys-RN | 8442898 |
| PubChem物质ID | 468591634 |
| MDL编号 | MFCD09951804 |
技术规格
| Appearance | White to Gray to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 262 °C |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 0.02 mg/l 25 °C |
| 溶解性（微溶于） | 丙酮 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | DG4438400 |
运输信息
| HS编码* | 2933.99-000 |
应用
Mitophagy research
Reference
- Iron loss triggers mitophagy through induction of mitochondrial ferritin
应用
Deferasirox: A Potent Chelating Agent with a Selective Affinity for Ferric Ion [Fe (III)]
Deferasirox (ICL670A) is a potent chelating agent with a selective affinity for ferric ion [Fe (III)]. Deferasirox binds with ferric ions to form neutral 2:1 (deferasirox:iron) complexes. And then, deferasirox has a lower binding affinity for other metals such as copper, aluminum and zinc than for iron. Deferasirox, an iron selective chelator, is used therapeutically in conditions of transfusional iron overload for the excretion of iron. (The product is for research purpose only.)
References
- ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
- ICL670A: preclinical profile (a review)
- Deferasirox: a review of its use in the management of transfusional chronic iron overload
- Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats
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