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CAS RN: 164656-23-9 | 产品编码: D5973
Dutasteride
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纯度/分析方法: >98.0%(HPLC)
别名：
- 度他雄胺
- (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-双(三氟甲基)苯基]-4a,6a-二甲基-2-氧代-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-十四氢-1H-茚并[5,4-f]喹啉-7-甲酰胺
- (5α,17β)-N-[2,5-双(三氟甲基)苯基]-3-氧代-4-氮杂雄-1-烯-17-甲酰胺
- (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide
产品文档：
| 产品编码 | D5973 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__7H__3__0F__6N__2O__2 = 528.54 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| 包装和容器
|
500MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 164656-23-9 |
| Reaxys-RN | 7401530 |
| PubChem物质ID | 468591669 |
| MDL编号 | MFCD00937869 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 246.0 to 250.0 °C |
| Specific rotation | +20.0 ～ +24.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 248 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 丙酮, 乙醇, 氯仿, 甲醇 |
GHS
相关法规
| RTECS# | NK9466600 |
运输信息
| HS编码* | 2937.29-000 |
应用
Dutasteride: A Selective Inhibitor of both the Type 1 and Type 2 Isoforms of 5α-Reductase
Dutasteride (GG745), a synthetic 4-azasteroid compound, is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5α-reductase, and blocks the conversion of testosterone [T0027] to 5α-dihydrotestosterone (DHT) [A0462] in target organs such as the prostate and scalp hair.1-4) It has been reported that dutasteride is a more potent inhibitor of type 1 (45-fold) and type 2 5α (2.5-fold) than finasteride [F0675] (a type 2 5α inhibitor) in vitro.4) Dutasteride also has been studied for its ability to reduce the incidence of prostate cancer.4) (The product is for research purpose only.)
References
- 1) Mechanism of Time-Dependent Inhibition of 5.alpha.-Reductases by .DELTA.1-4-Azasteroids: Toward Perfection of Rates of Time-Dependent Inhibition by Using Ligand-Binding Energies
- 2) Unique Preclinical Characteristics of GG745, A Potent Dual Inhibitor of 5AR
- 3) An overview on 5α-reductase inhibitors (a review)
- 4) Dutasteride: a review of its use in the management of prostate disorders (a review)
- 5) RP-HPLC method for the estimation of dutasteride in tablet dosage form
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技术规格
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