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CAS RN: 5580-20-1 | 产品编码: D6061
2'-Deoxy-4-thiouridine
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纯度/分析方法: >95.0%(HPLC)(qNMR)
别名：
- 2'-脱氧-4-硫尿苷
- 4-硫代-2'-脱氧尿苷
- 1-(2-脱氧-β-D-erythro-呋喃糖基)-4-硫酮基-3,4-二氢-2(1H)-嘧啶酮
- 1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-4-硫代-3,4-二氢嘧啶-2(1H)-酮
- 4-Thio-2'-deoxyuridine
- 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
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产品文档：
| 产品编码 | D6061 |
纯度/分析方法 
|
>95.0%(HPLC)(qNMR) |
| 分子式/分子量 | C__9H__1__2N__2O__4S = 244.27 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 5580-20-1 |
| Reaxys-RN | 888182 |
| MDL编号 | MFCD00058457 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 167.0 to 171.0 °C |
| Water | max. 4.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 169 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
2'-Deoxy-4-Thiouridine: A Photoactive Nucleoside Analog
4–thionucleosides, containing 2'-deoxy-4-thiouridine, are photoactive nucleoside analogs, and absorb light at wavelengths around 340 nm and, thus, can be selectively photo-activated.1,2) They exhibit a high photocrosslinking ability towards pyrimidine bases (particularly thymine) but also purine bases. In fact, oligonucleotides containing 2'-deoxy-4-thiouridine has been used for photocrosslinking studies of oligonucleotides.3,4) In addition, 2'-deoxy-4-thiouridine exhibits an anti-[herpes simplex virus (HSV)] activity,5) and is used for a post-synthetic modification of oligonucleotides through oxidative amination of 2'-deoxy-4-thiouridine, converting it on oligonucleotides into deoxycytidine derivates.6) (The product is for research purpose only.)
References
- 1) NMR and UV Studies of 4-thio-2'-deoxyuridine and its derivatives
- 2) Thionucleobases as intrinsic photoaffinity probes of nucleic acid structure and nucleic acid-protein interactions (a review)
- 3) Synthesis and Postsynthetic Modification of Oligodeoxynucleotides Containing 4-Thio-2'-deoxyuridine (ds4U)
- 4) Photoactivation of DNA thiobases as a potential novel therapeutic option
- 5) Anti-(herpes simplex virus) activity of 4’-thio-2’-deoxyuridines: a biochemical investigation for viral and cellular target enzymes
- 6) General Method for Post-Synthetic Modification of Oligonucleotides Based on Oxidative Amination of 4-Thio-2′-deoxyuridine
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