Emodin

References

• 1) Alizarin and Chrysazin Inhibit Biofilm and Hyphal Formation by Candida albicans
  • R.K. Manoharan, J.-H. Lee, Y.-G. Kim, J. Lee, Front. Cell. Infect. Microbiol. 2017, 7, 447.
• 2) Calcium-chelating alizarin and other anthraquinones inhibit biofilm formation and the hemolytic activity of Staphylococcus aureus
  • J.-H. Lee, Y.-G. Kim, S.Y. Ryu, J. Lee, Sci. Rep. 2016, 6, 19267.


应用
Research for antifouling agent against aquatic organism

Reference

• Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023
  • J. Bao, Y.-L. Sun, X.-Y. Zhang, Z. Han, H.-C. Gao, F. He, P.-Y. Qian, S.-H. Qi, J. Antibiot. 2013, 66, 219.


应用
Emodin: An Anthraquinone with a Wide Spectrum of Pharmacological Properties
Emodin is a natural occurring anthraquinone present in the roots and barks of numerous plants, molds, and lichens, and an active ingredient of various Chinese medicinal herbs. It has been reported that emodin has a wide spectrum of pharmacological properties, including diuretic, vasorelaxant, anti-bacterial, anti-viral, anti-ulcerogenic, anti-inflammatory, and anti-cancer effects. (The product is for research purpose only.)

References

• Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent (a review)
  • G. Srinivas, S. Babykutty, P. P. Sathiadevan, P. Srinivas, Med. Res. Rev. 2007, 27, 591.
• Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer (a review)
  • D. Shrimali, M. K. Shanmugam, A. P. Kumar, J. Zhang, B. K. H. Tan, K. S. Ahn, G. Sethi, Cancer Lett. 2013, 341, 139.
• Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
  • X. Dong, J. Fu, X. Yin, S. Cao, X. Li, L. Lin, Huyiligeqi, J. Ni. Phytother. Res. 2016, 30, 1207.


应用
Emodin: A Naturally Occurring Anthraquinone with Anti-Cancer and Anti-Inflammatory Activities
Emodin is a naturally occurring anthraquinone found in a variety of plants (e.g., rhubarb) used in traditional Chinese medicine.^1,2) Purified emodin has been reported to possess diverse effects, including anti-oxidation, anti-cancer and anti-inflammatory activities. Emodin is a pleiotropic molecule capable of interacting with several major molecular targets including, NF-κB, casein kinase II, HER2/neu, HIF-1α, AKT/mTOR, STAT3, CXCR4, topoisomerase II, p53, p21, and androgen receptors which are involved in inflammation and cancer.^2-4) (The product is for research purpose only.)

References

• 1) One single standard substance for the determination of multiple anthraquinone derivatives in rhubarb using high-performance liquid chromatography-diode array detection
  • X.-Y. Gao, Y. Jiang, J.-q. Lu, P.-F. Tu, J. Chromatogr. A 2009, 1216, 2118.
• 2) Anti-cancer properties of anthraquinones from Rhubarb (a review)
  • Q. Huang, G. Lu, H.-M. Shen, M. C. M. Chung, C. N. Ong, Med. Res. Rev. 2007, 27, 609.
• 3) Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent (a review)
  • G. Srinivas, S. Babykutty, P. P. Sathiadevan, P. Srinivas, Med. Res. Rev. 2007, 27, 591.
• 4) Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer (a review)
  • D. Shrimali, M. K. Shanmugam, A. P. Kumar, J. Zhang, B. K. H. Tan, K. S. Ahn, G. Sethi, Cancer Lett. 2013, 341, 139.


PubMed Literature