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CAS RN: 24169-02-6 | 产品编码: E0957
Econazole Nitrate
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 161 °C(dec.) |
| 水溶性 | 不溶 |
| 溶解性（微溶于） | 乙醇 |
| 溶解性（不溶于） | 乙醚 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | NI4450000 |
运输信息
| HS编码* | 2933.29-000 |
应用
Econazole Nitrate: An Imidazole Antifungal Reagent with other Activities.
Econazole nitrate is an imidazole antifungal reagent which is very closely related structurally to another imidazole derivative, miconazole nitrate [M1769]. It has broad-spectrum antimycotic activity. In addition, it is reported as a blocker of Ca2+ influx, and an inhibitor of steroid aromatization. Recently, various drug delivery systems have been reported to enhance the drug antifungal activity.
References
- Econazole: a review of its antifungal activity and therapeutic efficacy
- Econazole Nitrate (description, synthesis, physical properties, stability and degradation products)
- Inhibition of calcium transport pathways in thymic lymphocyte by econazole, miconazole, and SKF 96365
- Imidazole antimycotics: selective inhibitors of steroid aromatization and progesterone hydroxylation
- Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation
参考文献
技术文章
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