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CAS RN: 143491-57-0 | 产品编码: E1007
Emtricitabine
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | E1007 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__8H__1__0FN__3O__3S = 247.24 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 143491-57-0 |
| Reaxys-RN | 5908714 |
| PubChem物质ID | 253660241 |
| Merck Index (14) | 3565 |
| MDL编号 | MFCD00870151 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 153.0 to 157.0 °C |
| Specific rotation [a]20/D | -137.0 to -143.0 deg(C=0.25, MeOH) |
物性（参考值）
| 熔点 | 155 °C |
| 比旋光度 [α]D | -140° (C=0.25,MeOH) |
| 最大吸收波长 | 280 nm (H__2O) |
| 水溶性 | 可溶 |
| 在水中的溶解度 | 112 g/l 25 °C |
GHS
相关法规
| RTECS# | UW7360500 |
运输信息
| HS编码* | 2934.99-000 |
应用
Emtricitabine (FTC): a Nucleoside Reverse Transcriptase Inhibitor (NRTI)
Emtricitabine (FTC) is a nucleoside reverse transcriptase inhibitor (NRTI) that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus (HBV). FTC, after phosphorylated by cellular enzymes to emtricitabine 5'-triphosphate (FTC-TP), inhibits HIV and HBV reverse transcriptase (HIV-RT and HBV-RT).
References
- Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
- Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides
- Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus
- Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection
- Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV
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