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CAS RN: 31637-97-5 | 产品编码: E1359
Etofibrate
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纯度/分析方法: >98.0%(GC)
别名：
- 依托贝特
- 3-吡啶甲酸2-[2-(4-氯苯氧基)-2-甲基-1-氧代丙氧基]乙酯
- 烟酸2-[[2-(4-氯苯氧基)-2-甲基丙酰基]氧基]乙酯
- 2-[2-(4-Chlorophenoxy)-2-methyl-1-oxopropoxy]ethyl 3-Pyridinecarboxylate
- 3-Pyridinecarboxylic Acid 2-[2-(4-Chlorophenoxy)-2-methyl-1-oxopropoxy]ethyl Ester
- 2-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]oxy]ethyl Nicotinate
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 48.0 to 52.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 50 °C |
| 沸点 | 214 °C/0.3 mmHg |
GHS
相关法规
运输信息
| HS编码* | 2933.39-000 |
应用
Etofibrate: A Hybrid Hypolipidemic Agent which Combines Nicotinic Acid (Niacin) with Clofibrate
Etofibrate is a hypolipidemic fibrate which combines nicotinic acid (niacin) [N0082] with clofibrate [C0941]. After contact with plasma hydrolases, both active constituents are gradually released in a controlled-release manner. The fibrates, including etofibrate, are lower elevated serum lipids by decreasing the low density lipoprotein (LDL) fraction rich in cholesterol and the very low density lipoprotein (VLDL) fraction rich in triglycerides. In addition, fibrates increase the high density lipoprotein (HDL) cholesterol fraction. (The product is for research purpose only.)
References
- Studies with etofibrate in the rat. Part I: Effects on glycerol, free fatty acid and triacylglycerol metabolism
- Studies with etofibrate in the rat. Part II: a comparison of the effects of prolonged and acute administration on plasma lipids, liver enzymes and adipose tissue lipolysis
- Comparative study on the in vivo and in vitro antilipolytic effects of etofibrate, nicotinic acid and clofibrate in the rat
- High performance liquid chromatographic determination of etofibrate and its hydrolysis products
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