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CAS RN: 152044-54-7 | 产品编码: E1378
Epothilone B
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation [a]20/D | -40.0 to -44.0 deg (C=0.2, methanol) |
| Elemental analysis(Carbon) | 62.50 to 65.00 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 94 °C |
| 比旋光度 [α]D | -36° (C=0.2,MeOH) |
| 最大吸收波长 | 249 nm (MeOH) |
GHS
相关法规
| RTECS# | JG6799500 |
运输信息
| HS编码* | 2941.90-000 |
应用
Epothilone B: A Microtubule Inhibitor
Epothilone B, a natural macrolide compound, is a microtubule inhibitor belonging to a class of antineoplastic agents. Epothilone B was originally isolated from the cellulose-degrading myxobacteria Sorangium cellulosum. Epothilone B has a mode of action analogous to that of paclitaxel [P1632]. It binds directly to β-tubulin subunits on microtubules, stabilizing microtubules. It blocks cells in the mitotic phase of the cell division cycle, leading to cell death. Epothilone B has poor metabolic stability and unfavorable pharmacokinetics.1-4) Therefore, its analogs (e.g. Ixabepilone; BMS-247550) were synthesized and used in clinical.4) (The product is for research purpose only.)
文献
- 1) Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
- 2) Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties.
- 3) Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol)
- 4) Epothilones: Mechanism of action and biologic activity (a review)
- 5) In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry
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