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CAS RN: 220119-17-5 | 产品编码: E1500
Selamectin
×
纯度/分析方法: >95.0%(HPLC)
别名：
- 塞拉菌素
- (5Z)-25-环己基-4'-O-脱(2,6-二脱氧-3-O-甲基-α-L-arabino-吡喃己糖基)-5-脱甲氧基-25-脱(1-甲基丙基)-22,23-二氢-5-(羟基亚氨基)阿维菌素A1a
- (5Z)-25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a
产品文档：
补充产品信息:
This product has not been tested for potency and is guaranteed for chemical purity.
| 产品编码 | E1500 |
纯度/分析方法 
|
>95.0%(HPLC) |
| 分子式/分子量 | C__4__3H__6__3NO__1__1 = 769.97 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 220119-17-5 |
| Reaxys-RN | 10756416 |
| MDL编号 | MFCD31621085 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
物性（参考值）
GHS
| 危险性说明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相关法规
| RTECS# | CL1199500 |
运输信息
| HS编码* | 2932.20-000 |
应用
Selamectin: A Macrocyclic Lactone of the Avermectin Class of Anthelmintics
Selamectin is a macrocyclic lactone of the avermectin class of anthelmintics, which includes ivermectin [I0819].1,2) The mechanism of action of selamectin is not fully understood, but it is strongly suggested to be related to glutamate-gated and GABA-gated chloride channels in nematode muscles and nerves.3,4) Selamectin binds with high affinity to the nematode’s chloride channels. As a result, the nematode is believed to be paralyzed. (The product is for research purpose only.)
References
- 1) Selamectin: a novel broad-spectrum endectocide for dogs and cats (a review)
- 2) Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs
- 3) Chloride channels as tools for developing selective insecticides (a review)
- 4) Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects (a review)
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