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CAS RN: 43229-80-7 | 产品编码: F0881
Formoterol Fumarate
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Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| 产品编码 | F0881 |
| 分子式/分子量 | C__1__9H__2__4N__2O__4·^^1/__2C__4H__4O__4 = 402.45 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 10MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 43229-80-7 |
| Reaxys-RN | 8665977 |
| PubChem物质ID | 253661050 |
| Merck Index (14) | 4245 |
| MDL编号 | MFCD03093863 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 % (total of 2peaks) |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Water | 1.5 to 5.5 % |
物性（参考值）
| 最大吸收波长 | 284 nm |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 甲醇 |
| 溶解性（不溶于） | 乙醇, 乙醚 |
GHS
相关法规
| RTECS# | LQ2988000 |
运输信息
| HS编码* | 2924.29-000 |
应用
Formoterol Fumarate: A Long-Acting and Selective β2-Adrenoceptor Agonist (LABA)
Formoterol fumarate is a long-acting and selective β2-adrenoceptor agonist (LABA) such as indacaterol maleate [I0927], causing bronchodilation by relaxing the smooth muscle in the airway. Formoterol has more potent activity than short acting β2-adrenoceptor agonist, such as salbutamol [S0531]. Combination inhalers containing formoterol fumarate and a corticosteroid (eg. budesonide [B3909], beclometasone dipropionate [B4464], fluticasone propionate [F0525] or mometasone furoate [M2354]) are often used for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. (The product is for research purpose only.)
References
- Formoterol: pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective β2-adrenoceptor agonist bronchodilator (a review)
- Formoterol: an update of its pharmacological properties and therapeutic efficacy in the management of asthma (a review)
- Why are long-acting beta-adrenoceptor agonists long-acting?
- Pharmacological basis for duration of effect: formoterol and salmeterol versus short-acting β2-adrenoceptor agonists (a review)
- Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells
- Chiral HPLC analysis of formoterol stereoisomers and thermodynamic study of their interconversion in aqueous pharmaceutical formulations
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