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CAS RN: 57044-25-4 | 产品编码: G0363
(R)-(+)-Glycidol
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技术规格
| Appearance | Colorless to Light yellow clear liquid |
| Purity(GC) | min. 98.0 % |
| Optical purity(GC) | min. 98.0 ee% |
物性（参考值）
| 沸点 | 57 °C/11 mmHg |
| 闪点 | 72 °C |
| 比重 | 1.12 |
| 比旋光度 [α]D | 15° (neat) |
| 折射率 | 1.43 |
| 水溶性 | 完全混溶 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H331 : Toxic if inhaled. H302 + H312 : Harmful if swallowed or in contact with skin. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H370 : Causes damage to organs. H373 : May cause damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H350 : May cause cancer. H335 : May cause respiratory irritation. H227 : Combustible liquid. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
相关法规
| RTECS# | RR0508000 |
运输信息
| UN编号 | UN2810 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2910.90-000 |
应用
Synthesis of (S)-glycol nucleosides and (S)-phosphoramidites
Typical procedure (Synthesis of the glycol thymine nucleoside (2)): To a solution of (R)-glycidol (1.0 mL) and Et3N (5.4 mL) in CH2Cl2 (34 mL) was added DMTrCl (6.45 g). After 12 h, the reaction mixture was poured into sat. NaHCO3 (50 mL). The organic layer was evaporated; the residue was dissolved in EtOAc, washed with sat. NaHCO3, and purified by silica gel chromatography (elute: hexane/EtOAc/Et3N = 10/1/0.01) to give the DMTr-glycidol (1) as an oil (5.98 g, quant.). A mixture of thymine (0.63 g) and NaH (60 % dispersion in paraffin liquid, 42 mg) in DMF (8 mL) was stirred at rt for 2 h. The DMF (10 mL) solution of the DMTr-glycidol (1) (1.79 g) was added, and the resulting mixture was heated at 110 °C for 20 h. The DMF was evaporated, the residue was extracted with EtOAc, and purified by silica gel chromatography (elute: hexanes/EtOAc/Et3N = 1/2/0.01) to give the glycol thymine nucleoside (2) as a colorless foam (1.22 g, 49 %).
References
参考文献