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CAS RN: 56974-61-9 | 产品编码: G0464
Gabexate Mesylate
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | G0464 |
纯度/分析方法 
|
>97.0%(N) |
| 分子式/分子量 | C__1__6H__2__3N__3O__4·CH__4O__3S = 417.48 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 56974-61-9 |
| 相关CAS RN
|
39492-01-8 |
| Reaxys-RN | 5702026 |
| PubChem物质ID | 253660880 |
| Merck Index (14) | 4320 |
| MDL编号 | MFCD00210299 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 94.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 89.0 to 93.0 °C |
物性（参考值）
| 熔点 | 91 °C |
| 溶解性（可溶于） | 甲醇 |
| 溶解性（微溶于） | 丙酮 |
| 溶解性（不溶于） | 乙醚 |
GHS
相关法规
| RTECS# | DG2800800 |
运输信息
| HS编码* | 2925.29-000 |
应用
Gabexate Mesylate: A Synthetic Non-Peptide Protease Inhibitor
Gabexate mesylate is a synthetic non-peptide protease inhibitor. It inhibits trypsin, kallikrein, thrombin, plasmin, C1 esterase, and etc. Gabexate mesylate inhibit thrombin and activated factor X, being independent of plasma antithrombin level. Gabexate mesylate is used as anticoagulants for the treatment of disseminated intravascular coagulation (DIC). (The product is for research purpose only.)
References
- FOY: [ethyl-p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro
- Gabexate mesylate and pivmecillinam hydrochloride (a review)
- D. F. Weetman, Drugs Today 1978, 14, 411.
- Competitive inhibition of swine kidney copper amine oxidase by drugs: amiloride, clonidine, and gabexate mesylate
- Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α producation by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes
- Gabexate mesilate inhibits colon cancer growth, invasion, and metastasis by reducing matrix metalloproteinases and angiogenesis
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