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CAS RN: 58-93-5 | 产品编码: H1274
Hydrochlorothiazide
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纯度/分析方法: >97.0%(HPLC)(N)
别名：
- 氢氯噻嗪
- 7-(氨基磺酰基)-6-氯-3,4-二氢-(2H)-1,2,4-苯并噻二嗪1,1-二氧化物
- 6-氯-3,4-二氢-(2H)-1,2,4-苯并噻二嗪-7-磺酰胺1,1-二氧化物
- 6-氯-7-磺酰胺-3,4-二氢-(2H)-1,2,4-苯并噻二嗪1,1-二氧化物
- 7-(Aminosulfonyl)-6-chloro-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-Dioxide
- 6-Chloro-3,4-dihydro-(2H)-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide
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产品文档：
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 269 °C |
| 最大吸收波长 | 318 nm (H__2O) |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 722 mg/l 25 °C |
| 溶解性（可溶于） | 甲醇, 丙酮, 乙醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H351 : Suspected of causing cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | DK9100000 |
运输信息
| HS编码* | 2935.90-000 |
应用
Hydrochlorothiazide: A Thiazide Diuretic
Hydrochlorothiazide, a thiazide diuretic, affects the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately molecular equivalent amounts. Although the mechanism of the antihypertensive effect remains unknown exactly, thiazide diuretics are often used with AT1 receptor antagonists, especially valsartan [V0112], in clinical use. (The product is for research purpose only.)
References
- Sodium chloride absorption by the urinary bladder of the winter flounder. A thiazide-sensitive, electrically neutral transport system
- Valsartan/hydrochlorothiazide. A review of its pharmacology, therapeutic efficacy and place in the management of hypertension
- Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics (a review)
- Analytical profiles of drug substances. Hydrochlorothiazide (a review on the detection, preparation, and metabolism)
- Simultaneous determination of valsartan and hydrochlorothiazide in tablets by first-derivative ultraviolet spectrophotometry and LC
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