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CAS RN: 66852-54-8 | 产品编码: H1457
Halobetasol Propionate

产品编码 | H1457 |
纯度/分析方法 ![]() |
>98.0%(HPLC) |
分子式/分子量 | C__2__5H__3__1ClF__2O__5 = 484.96 |
外观与形状(20°C) | 固体 |
储存温度 ![]() |
冷藏 (0-10°C) |
应避免的情况 | 加热 |
包装和容器 ![]() |
25MG-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 66852-54-8 |
Reaxys-RN | 11109992 |
MDL编号 | MFCD00866013 |
技术规格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Specific rotation [a]20/D | +89.0 to +93.0 deg(C=1, Dioxane) |
NMR | confirm to structure |
物性(参考值)
熔点 | 221 °C |
比旋光度 [α]D | 91° (C=1,Dioxane) |
GHS
象形图 |
![]() |
信号词 | Warning |
危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
RTECS# | TU3723500 |
运输信息
HS编码* | 2937.22-000 |
应用
Halobetasol propionate: A Super-Potent Corticosteroid
Halobetasol propionate is a super-potent corticosteroid with additional fluorine at the 6α position when compared with clobetasol 17-propionate [C2612]. The additional fluorine in the 6α position further increases its topical anti-inflammatory and antiproliferative activities. In addition, an ointment formulation in combination of halobetasol propionate and fusidic acid [F1007] for treatment of dermal conditions have been reported. (The product is for research purpose only.)
References
- Halobetasol versus clobetasol: A study of potency
- A degradation product of halobetasol propionate-characterization and structure
- Formulation and evaluation of novel combined halobetasol propionate and fusidic acid ointment
- Spectrophotometric determination of clobetasol propionate, halobetasol propionate, quinagolide hydrochloride, through charge transfer complexation
- Screening for corticosteroids in topical pharmaceuticals by HPLC with a scanning ultraviolet detector
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