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CAS RN: 178306-52-0 | 产品编码: H1568
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid
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| 产品编码 | H1568 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__6H__1__6O__4 = 272.30 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 178306-52-0 |
| Reaxys-RN | 8413483 |
| PubChem物质ID | 354334235 |
| MDL编号 | MFCD11113284 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +11.0 to +15.0 deg(C=1.8, EtOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 120 °C(dec.) |
| 比旋光度 [α]D | 13° (C=1.8,EtOH) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2918.99-000 |
应用
A Key Synthetic Intermediate of Ambrisentan
This product is a key synthetic intermediate of ambrisentan [A2966] which is a highly selective Endothelin-A (ETA) receptor antagonist used for the treatment of pulmonary arterial hypertension (PAH).
References
- Multistep process for preparation of ambrisentan and darusentan
- R. M. Satyanarayana, C. Nagaraju, A. K. Ramprasad, WO/2010/070658.
- Process for preparation of ambrisentan from (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid and a 4,6-dimethylpyrimidine derivative
- R. M. Gidwani, C. Janssen, A. Mathieu, W. Albrecht, F. Lehmamnn, WO/2010/091877.
- Rapid determination of ambrisentan enantiomers by enantioselective liquid chromatography using cellulose-based chiral stationary phase in reverse phase mode
- LC-MS/MS characterization of forced degradation products of ambrisentan: development and validation of a stability-indicating RP-HPLC method
应用
A Synthetic Intermediate of Endothelin Receptor Antagonists
This reagent is used for synthesis of endothelin receptor antagonists, such as darusentan [CAS: 171714-84-4].
References
- Discovery and Synthesis of (S)-3-[2-(3,4-Dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic Acid (LU 302872), a Novel Orally Active Mixed ETA/ETB Receptor Antagonist
- Structural Similarity and Its Surprises: Endothelin Receptor Antagonists - Process Research and Development Report
参考文献