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CAS RN: 3258-02-4 | 产品编码: H1803
N4-Hydroxycytidine
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| 产品编码 | H1803 |
纯度/分析方法 
|
>95.0%(HPLC) |
| 分子式/分子量 | C__9H__1__3N__3O__6 = 259.22 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,湿气 (吸湿),加热 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 3258-02-4 |
| Reaxys-RN | 32372 |
| MDL编号 | MFCD01675695 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Water | max. 7.0 % |
| NMR | confirm to structure |
物性（参考值）
GHS
相关法规
| RTECS# | YU8080000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Inhibitor Causing Mutations during Viral Replication by RNA-Dependent RNA Polymerase
References
- β-D-N4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome
- Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
应用
N4-Hydroxycytidine: A Potent and Selective Viral RNA-Dependent RNA polymerase (RdRp) Inhibitor
N4-Hydroxycytidine (EIDD-1931), an antiviral ribonucleoside analog, is an active metabolite of molnupiravir which has activity against a number of RNA viruses.1,2) The RNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for RNA virus replication processes and catalyzes the replication of RNA from an RNA template.3) Because of this, they are often recognized as good targets for antiviral agents. It has been reported that N4-hydroxycytidine acts as a viral RdRp inhibitor of RNA viruses.1,4,5) (The product is for research purpose only.)
References
- 1) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- 2) Human safety, tolerability, and pharmacokinetics of molnupiravir, a novel broad-spectrum oral antiviral agent with activity against SARS-CoV-2
- 3) RNA dependent RNA polymerases: insights from structure, function and evolution
- 4) β-D-N4-Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome
- 5) Small-molecule antiviral β-D-N4-hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance
技术文章
[Featured Products] RNA-dependent RNA Polymerase Inhibitors[产品拾贝] 以RNA依赖性RNA聚合酶的病毒复制阶段为靶点诱发突变的抗病毒剂
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