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CAS RN: 30414-00-7 | 产品编码: H1866
5-(Hydroxymethyl)uridine
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 5-(羟甲基)尿苷
- 5-羟甲基尿苷
- 1-[(2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基]-5-(羟甲基)嘧啶-2,4(1H,3H)-二酮
- 5-Hydroxymethyluridine
- 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
产品文档：
| 产品编码 | H1866 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__0H__1__4N__2O__7 = 274.23 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| 包装和容器
|
200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 30414-00-7 |
| Reaxys-RN | 38534 |
| MDL编号 | MFCD00057401 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 164.0 to 168.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 166 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
5-(hydroxymethyl)uridine: A Base-Modified Ribonucleoside Used in SMUG1 and Epigenetics Studies
Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) is a base excision repair enzyme that not only recognizes and removes uracil and oxidized pyrimidines from DNA, but is also capable of processing modified RNA substrates.1,2) There are reports that SUMG1 contributes to rRNA quality control, in part by regulating the level of 5-(hydroxymethyl)uridine (5hmU) in the cell.1,2) It is also possible that 5-(hydroxymethyl)uridine acts as an epigenetic biomarker.3)
References
- 1) The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control
- 2) RNA metabolism guided by RNA modifications: the role of SMUG1 in rRNA quality control (a review)
- 3) Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both?
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