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CAS RN: 138402-11-6 | 产品编码: I0859
Irbesartan
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| 产品编码 | I0859 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__5H__2__8N__6O = 428.54 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 138402-11-6 |
| Reaxys-RN | 6620400 |
| PubChem物质ID | 172088930 |
| Merck Index (14) | 5083 |
| MDL编号 | MFCD00864464 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 184.0 to 188.0 °C |
物性（参考值）
| 熔点 | 188 °C |
| 水溶性 | 不溶 |
GHS
| 危险性说明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相关法规
| RTECS# | HM2950270 |
运输信息
| HS编码* | 2933.29-000 |
应用
Selective AT1 Subtype Angiotensin II Receptor Antagonists
References
- Angiotensin Type 1 Receptor Blockers Induce Peroxisome Proliferator-Activated Receptor-gamma Activity
- Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats
- Pharmacological characterization of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist
- C. Cazaubon, J. Gougat, F. Bousquet, P. Guiraudou, R. Gayraud, C. Lacour, A. Roccon, G. Galindo, G. Barthelemy, B. Gautret, J. Pharmacol. Exp. Ther. 1993, 265, 826.
- Role of cytochrome P-4502C9 in irbesartan oxidation by human liver microsomes
- M. Bourrié, V. Meunier, Y. Berger, G. Fabre, Drug Metab. Dispos. 1999, 27, 288.
应用
Irbesartan: A Long-Active Specific Competitive Angiotensin II Type 1 (AT1) Receptor Antagonist
Angiotensin II, a peptide hormone, is a potent vasoconstrictor formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Angiotensin II can activate two different receptors, AT1 and AT2, both of which are coupled to G-protein. The most important vasoconstrictor actions of angiotensin II are mediated through AT1 receptors. Irbesartan is a long-active specific competitive antagonist of AT1 receptors with a much greater affinity for the AT1 receptor than for the AT2 receptor, and no agonist activity. Irbesartan selectively binds to the AT1 receptor and competitively binds the endogenous hypertensive (vasoconstrictor) substance angiotensin II, and has an antihypertensive effect. For your reference, [B4143] is a key synthetic intermediate of irbesartan. (The product is for research purpose only.)
References
- Irbesartan: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in the management of hypertension
- The new angiotensin II receptor antagonist, irbesartan: pharmacokinetic and pharmacodynamics considerations (a review)
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