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CAS RN: 85801-02-1 | 产品编码: I0943
Indometacin Farnesil
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| 产品编码 | I0943 |
纯度/分析方法 
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>98.0%(HPLC) |
| 分子式/分子量 | C__3__4H__4__0ClNO__4 = 562.15 |
| 外观与形状（20°C） | 液体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| CAS RN | 85801-02-1 |
| PubChem物质ID | 354333527 |
| MDL编号 | MFCD00870661 |
技术规格
| Appearance | Light yellow to Yellow to Orange clear liquid |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 2.00 to 3.00 % |
| NMR | confirm to structure |
物性（参考值）
| 闪点 | 333 °C |
| 水溶性 | 不溶 |
| 溶解性（微溶于） | 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | NL3522820 |
运输信息
| HS编码* | 2933.99-000 |
应用
Indometacin Farnesil: A Prodrug of the Non-Steroidal Anti-Inflammatory Drug Indomethacin
Indometacin farnesil is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) indomethacin [I0655], designed to reduce the occurrence of side-effects in the gastrointestinal tract. When indometacin farnesil is administered orally, it is absorbed through the gastrointestinal tract as unchanged drug which is mildly injurious to the tract. Indometacin farnesil is metabolized to indomethacin, the active form, in the liver and kidney, and this indomethacin inhibits prostaglandin biosynthesis by inhibiting cyclooxygenase (COX). (The product is for research purpose only.)
References
- Inhibitory effect of indomethacin farnesil, a novel antiinflammatory prodrug, on carrgeenin-induced inflammation in rats
- Metabolic fate of indomethacin farnesil, a prodrug of indomethacin: characteristic biotransformation of indomethacin farnesil in rats
- Ulcerogenicity and effect on inhibition of prostaglandin generation of indometacin farnesil, a prodrug of indomethacin, in rat gastric mucosa: comparison with indomethacin or loxoprofen
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