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CAS RN: 870281-82-6 | 产品编码: I1005
Idelalisib
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 200MG |
S$364.50
|
3 | 19 | 下单后约2周内可以发货 |
|
| 产品编码 | I1005 |
纯度/分析方法 
|
>98.0%(HPLC)(N) |
| 分子式/分子量 | C__2__2H__1__8FN__7O = 415.43 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 870281-82-6 |
| Reaxys-RN | 25802168 |
| MDL编号 | MFCD19443647 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
物性（参考值）
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2933.59-000 |
应用
Idelalisib: A Selective Inhibitor of Phosphatidylinositol-3-Kinase (PI3Kδ)
Idelalisib is a selective inhibitor of phosphatidylinositol-3-kinase (PI3Kδ), which mediates B-cell receptor (BCR) signaling and microenvironmental support signals that promote the growth and survival of malignant B lymphocytes. It has been reported that idelalisib induces apoptosis and inhibits proliferation in cell lines derived from malignant B lymphocytes and in primary tumor cells. Recently, idelalisib has been approved for the treatment of several hematological malignancies. (The product is for research purpose only.)
References
- J. R. Somoza, D. Koditek, A. G. Villaseñor, N. Novikov, M. H. Wong, A. Liclican, W. Xing, L. Lagpacan, R. Wang, B. E. Schultz, G. A. Papalia, D. Samuel, L. Lad, M. E. McGrath, J. Biol. Chem. 2015, 290, 8439.
- C. U. Niemann, A. Wiestner, Semin. Cancer Biol. 2013, 23, 410.
- J. A. Burger, K. Okkenhaug, Nat. Rev. Clin. Oncol. 2014, 11, 184.
- A. Markham, Drugs 2014, 74, 1701.
技术文章
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