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CAS RN: 34552-83-5 | 产品编码: L0154
Loperamide Hydrochloride
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Methanol | almost transparency |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 223 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 二氯甲烷, 乙醇 |
| 溶解性（不溶于） | 乙醚 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | TM4960000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2933.39-000 |
应用
Loperamide Hydrochloride: An Opioid Receptor Agonist in the Gastrointestinal Tract
Loperamide hydrochloride, an opioid agonist, reduces gastrointestinal motility in animals and human through activation of opioid receptors in the gastrointestinal tract. It cannot readily cross the blood-brain barrier, and does not appear to exert opiate activity in human. Loperamide is used as an antidiarrheal agent. (The product is for research purpose only.)
References
- Loperamide: survey of studies on mechanism of its antidiarrheal activity (a review)
- Delivery of loperamide across the blood-brain barrier with Polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles
- Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity
- Loperamide and P-glycoprotein inhibition: assessment of the clinical relevance (a review)
- Loperamide hydrochloride
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