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CAS RN: 137-58-6 | 产品编码: L0156
Lidocaine
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 66.0 to 70.0 °C |
| Solubility in Methanol | almost transparency |
物性（参考值）
| 熔点 | 69 °C |
| 沸点 | 182 °C/4 mmHg |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 410 mg/l 30 °C |
| 溶解性（可溶于） | 醇, 苯, 氯仿, 乙醚 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H302 : Harmful if swallowed. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H317 : May cause an allergic skin reaction. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P272 : Contaminated work clothing should not be allowed out of the workplace. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | AN7525000 |
运输信息
| HS编码* | 2924.29-000 |
应用
Lidocaine: A Voltage Gated Sodium Channel Blocker
Lidocaine is widely used for regional anesthesia and postoperative pain relief, and these effects involve the blockade of voltage-dependent sodium channels which play a key role in the pathogenesis of neuropathic pain. Thus, lidocaine stabilizes the neuronal cell membrane by inhibiting the movement of sodium ions into a nerve cell. Lignocaine is also a class IB antiarrhythmic agent as a sodium channel blocker. Lidocaine is metabolized rapidly by CYP1A2 and CYP3A4 in liver to main active metabolites, monoethylglycine xylidide (MEGX) [N1171] and glycinexylidide (GX) [G0579]. (The product is for research purpose only.)
References
- Lidocaine block of cardiac sodium channels
- Molecular determinants of state-dependent block of Na+ channels by local anesthetics
- The role of sodium channels in chronic inflammatory and neuropathic pain (a review)
- High-performance liquid chromatography-tandem electrospray mass spectrometry for the determination of lidocaine and its metabolites in human plasma and urine
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