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CAS RN: 1180-71-8 | 产品编码: L0258
Limonin
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| 产品编码 | L0258 |
纯度/分析方法 
|
>95.0%(HPLC) |
| 分子式/分子量 | C__2__6H__3__0O__8 = 470.52 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 1180-71-8 |
| Reaxys-RN | 1695716 |
| PubChem物质ID | 253661951 |
| Merck Index (14) | 5494 |
| MDL编号 | MFCD00075922 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 95.0 area% |
| Specific rotation [a]20/D | -116 to -120 deg(C=1, Acetone) |
物性（参考值）
| 熔点 | 298 °C |
| 比旋光度 [α]D | -117° (C=1,Acetone) |
| 最大吸收波长 | 285 nm |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 四氢呋喃, 丙酮 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | RR1122000 |
运输信息
| HS编码* | 2932.99-000 |
应用
Limonin: A Chemically-Induced Carcinogenesis Inhibitor and a HIV-1 Replication Inhibitor
Limonin is a non-volatile triterpeneis which is one of two major bitter principles in citrus juice, especially in grapefruit juice. Limonin has been found to inhibit chemical induced carcinogenesis. Limonin is an inducer of glutathione S-transferase, a major detoxifying enzyme system. Additionally, limonin has been reported to inhibit in vitro HIV-1 protease activity.
References
- Limonin and limonoids. Chemistry, biochemistry, and juice bitterness (a review)
- Limonin and nomilin inhibitory effects on chemical-induced tumorigenesis (a review)
- Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin
- Antioxidant Activity of Citrus Limonoids, Flavonoids, and Coumarins
- Suppression of colon carcinogenesis by bioactive compounds in grapefruit
- Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells
参考文献
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