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CAS RN: 130018-87-0 | 产品编码: L0264
Levocetirizine Dihydrochloride
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| 产品编码 | L0264 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__1H__2__5ClN__2O__3·2HCl = 461.81 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 130018-87-0 |
| 相关CAS RN
|
130018-77-8 |
| Reaxys-RN | 9455577 |
| PubChem物质ID | 253661576 |
| Merck Index (14) | 2022 |
| MDL编号 | MFCD07366507 |
技术规格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 214 °C |
| 在水中的溶解度 | 946 g/l |
| 溶解性（不溶于） | 丙酮 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | AG0990000 |
运输信息
| HS编码* | 2933.59-000 |
应用
Levocetirizine Dihydrochloride: A New Histamine H1 Antagonist with a Superior Affinity for H1 Receptors over Its Racemate, Cetirizine [C2316]
Levocetirizine dihydrochloride is a new second-generation histamine H1 antagonist, developed from cetirizine [C2316]. Chemically, levocetirizine is the active R-enantiomer of cetirizine. Levocetirizine has a superior affinity and selectivity for H1 receptors over racemic cetirizine or the S-enantiomer, and has a favorable pharmacokinetic profile.
References
- Binding characteristics of cetirizine and levocetirizine to human H1 histamine receptors: contribution of Lys191 and Thr194
- Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1- receptor antagonists
- Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans (a review)
- Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine a comparative review
- Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies
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