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CAS RN: 118288-08-7 | 产品编码: L0341
Lafutidine
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| 产品编码 | L0341 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__2H__2__9N__3O__4S = 431.55 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 118288-08-7 |
| Reaxys-RN | 8045494 |
| PubChem物质ID | 468592156 |
| Merck Index (14) | 5347 |
| MDL编号 | MFCD00867520 |
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 97.0 to 101.0 °C |
物性（参考值）
| 熔点 | 99 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | AC2957000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Lafutidine: A Histamine H2 Receptor Antagonist with Gastric Antisecretory and Gastroprotective Activities
Lafutidine (FRG-8813) is a histamine H2 receptor antagonist with gastric antisecretory and gastroprotective activities. It exhibits potent and long-lasting H2 antagonism and prolonged antisecretion. In addition, it shows gastroprotective effects (increased gastric mucosal blood flow and gastric mucus secretion) against gastric mucosal damage through capsaicin-sensitive afferent nerves.
References
- Gastroprotective activity of FRG-8813, a novel histamine H2-receptor antagonist, in rats
- Unique profile of lafutidine, a novel histamine H2-receptor antagonist-mucosal protection throughout gastrointestinal tract mediated by capsaicin-sensitive afferent neurons (a review)
- Determination of lafutidine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry: Application to a bioequivalence study
- Analytical method development and validation of lafutidine in tablet dosage form by RP-HPLC
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