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CAS RN: 162607-15-0 | 产品编码: M2840
4-Methyl-2-thiopheneboronic Acid (contains varying amounts of Anhydride)
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(Neutralization titration) | 97.0 to 114.0 % |
| NMR | confirm to structure |
物性（参考值）
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
AmpC β-lactamase inhibitor
The primary resistance mechanism of microbes to β-lactam antibiotics is hydrolysis of the antibiotics by β-lactamase.1) 4-Methyl-2-thiopheneboronic acid is one of boronic acid compounds having β-lactamase (AmpC) inhibition activity (Ki = 0.50 ± 0.05 μM).2)
References
- 1) β-Lactamases and β-Lactamase Inhibitors in the 21st Century
- 2) Structure-Based Enhancement of Boronic Acid-Based Inhibitors of AmpC β-Lactamase
参考文献