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CAS RN: 956317-36-5 | 产品编码: M2935
5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic Acid

产品编码 | M2935 |
纯度/分析方法 ![]() |
>98.0%(T)(HPLC) |
分子式/分子量 | C__1__0H__9N__3O__2 = 203.20 |
外观与形状(20°C) | 固体 |
储存温度 ![]() |
室温 (15°C以下阴凉干燥处) |
包装和容器 ![]() |
1G-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 956317-36-5 |
Reaxys-RN | 15594863 |
PubChem物质ID | 354334352 |
MDL编号 | MFCD18382679 |
技术规格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Neutralization titration) | min. 98.0 % |
Melting point | 173.0 to 177.0 °C |
Solubility in Methanol | almost transparency |
物性(参考值)
熔点 | 175 °C |
溶解性(可溶于) | 甲醇 |
GHS
象形图 |
![]() |
信号词 | Warning |
危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
HS编码* | 2933.99-000 |
应用
A Synthetic Intermediate of Suvorexant (MK-4305)
This product is used for the synthesis of suvorexant (MK-4305) which is a dual orexin receptor antagonist (DORA) used for the treatment of insomnia.
References
- Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment ofInsomnia
- The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder
- Enantioselective Synthesis of a Dual Orexin Receptor Antagonist
参考文献
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