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CAS RN: 70476-82-3 | 产品编码: M3110
Mitoxantrone Dihydrochloride
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纯度/分析方法: >97.0%(HPLC)
别名：
- 米托蒽醌二盐酸盐
- 1,4-二羟基-5,8-双[[2-[(2-羟乙基)氨基]乙基]氨基]蒽醌二盐酸盐
- 1,4-二羟基-5,8-双[[2-[(2-羟乙基)氨基]乙基]氨基]蒽-9,10-二酮二盐酸盐
- 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone Dihydrochloride
- 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthracene-9,10-dione Dihydrochloride
产品文档：
| 产品编码 | M3110 |
| 纯度/分析方法 | >97.0%(HPLC) |
| 分子式/分子量 | C__2__2H__2__8N__4O__6·2HCl = 517.40 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 70476-82-3 |
| 相关CAS RN | 65271-80-9 |
| Reaxys-RN | 4835931 |
| PubChem物质ID | 468592271 |
| Merck Index (14) | 6217 |
| MDL编号 | MFCD00242943 |
技术规格
| Appearance | Dark green to Dark purple to Black powder to crystal |
| Purity(Argentometric Titration) | min. 95.0 % |
| Purity(HPLC) | min. 97.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 267 °C(dec.) |
| 最大吸收波长 | 660 nm (H__2O) |
| 溶解性（微溶于） | 甲醇 |
| 溶解性（不溶于） | 丙酮, 氯仿 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H310 : Fatal in contact with skin. H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H351 : Suspected of causing cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
相关法规
| RTECS# | CB0386900 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | II |
| HS编码* | 2922.50-000 |
应用
Virus research
References
- Mitoxantrone modulates a heparan sulfate‑spike complex to inhibit SARS‑CoV‑2 infection
- Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone
- Developing a Dynamic Pharmacophore Model for HIV-1 Integrase
- Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells
- Experimental antitumor activity of aminoanthraquinones
- Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones
- Mechanism of Action of Topoisomerase II-Targeted Antineoplastic Drugs
- Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer
- Mechanism of action of mitoxantrone (a review)
- HPLC analysis of mitoxantrone in mouse plasma and tissues: Application in a pharmacokinetic study
- Mitoxantrone hydrochloride (a review on the description, synthesis, physical properties, stability, pharmacology, and detection)
应用
Mitochondria research
Reference
应用
Mitoxantrone Dihydrochloride: A Synthetic Anthracycline Antitumor Agent with Improved Tolerability
Mitoxantrone [M3133] and its dihydrochloride are synthetic anthracycline antitumor agents that are structurally similar to doxorubicin hydrochloride [D4193] and daunorubicin hydrochloride [D4532]. Mitoxantrones intercalate into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. .Mitoxantrones also inhibit DNA repair by inhibiting topoisomerase II which results in fragmentation of DNA. Mitoxantrones display an improved tolerability profile compared with doxorubicin and other anthracyclines, but cross-resistance with the anthracyclines has been demonstrated. (The product is for research purpose only.)
References
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