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CAS RN: 520-85-4 | 产品编码: M3113
Medroxyprogesterone
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 215.0 to 220.0 °C |
| Specific rotation [a]20/D | +73.0 to +77.0 deg(C=1, CHCL3) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 217 °C |
| 比旋光度 [α]D | 75° (C=1,CHCl3) |
| 最大吸收波长 | 241 nm (EtOH) |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 2.95 mg/l 25 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | TU5300000 |
运输信息
| HS编码* | 2937.90-000 |
应用
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Medroxyprogesterone has been reported to act as a germinant for Clostridium sordellii spores (ED50 = 22.1 μM).4)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline Compared to Vancomycin When Combined with Germinants To Disrupt the Life Cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) Progesterone Analogs Influence Germination of Clostridium sordellii and Clostriduim difficile Spores In Vitro
PubMed Literature