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CAS RN: 927021-43-0 | 产品编码: M3117
1-Methyl-1-n-octylpyrrolidinium Bis(trifluoromethanesulfonyl)imide
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技术规格
| Appearance | Colorless to Light orange to Yellow clear liquid |
| Purity(Ion exchange titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | -12 °C |
| 比重 | 1.30 |
| 折射率 | 1.43 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2935.90-000 |
应用
Mitiglinide Calcium: A Fast-Acting Insulin-Releasing Agent
Mitiglinide calcium (KAD-1229; s 21403) is a glitinide class non-sulfonylurea insulinotropic agent with rapid onset. More rapidly than that of sulfonylurea antidiabetics, mitiglinide inhibits ATP-gated K+ channels and thereby causes depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. (The product is for research purpose only.)
References
- Novel rapid- and short-acting hypoglycemic agent, a calcium(2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) that acts on the sulfonylurea receptor: comparison of effects between KAD-1229 and gliclazide.
- The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.
- Effects of mitiglinide (s 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel
- Mitiglinide: a novel agent for the treatment of type 2 diabetes mellitus (a review)
- Simple, sensitive, and rapid LC-ESI-MS method for quantification of mitiglinide in human urine
- 新規速効型インスリン分泌促進薬ミチグリニドカルシウム水和物（グルファスト®錠）の薬理学的特徴および臨床試験成績
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