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CAS RN: 113507-06-5 | 产品编码: M3136
Moxidectin
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| 产品编码 | M3136 |
纯度/分析方法 
|
>98.0%(N) |
| 分子式/分子量 | C__3__7H__5__3NO__8 = 639.83 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷冻 (-20°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 113507-06-5 |
| Reaxys-RN | 4649146 |
| PubChem物质ID | 468592289 |
| Merck Index (14) | 6290 |
| MDL编号 | MFCD00866560 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 130.0 to 134.0 °C |
物性（参考值）
| 熔点 | 132 °C |
| 比旋光度 [α]D | 140° (C=1,CHCl3) |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H410 : Very toxic to aquatic life with long lasting effects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P391 : Collect spillage. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | PY5438800 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2932.99-000 |
应用
Moxidectin: A Macrocyclic Lactone with Anthelmintic Activity
Moxidectin, a macrocyclic lactone, is an anthelmintic and a semisynthetic methoxime derivative of naturally occurring nemadectin. It is well known for the action against a broad range of animalparasites. The precise mechanism of action is unknown, but studies with nematodes suggest that moxidectin binds to glutamate-gated chloride channels (GluCl), gamma-aminobutyric acid (GABA) receptors and/or ATP-binding cassette (ABC) transporters, causing muscle paralysis and death of the parasite. (The product is for research purpose only.)
References
- Moxidectin: a review of chemistry, pharmacokinetics and use in horses (a review)
- Macrocyclic lactones in the treatment and control of parasitism in small companion animals (a review)
- Analysis of avermectin and moxidectin residues in milk by liquid chromatography-tandem mass spectrometry using an atmospheric pressure chemical ionization/atmospheric pressure photoionization source
- Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography-tandem mass spectrometry with rapid polarity switching
- Analytical profile of moxidectin (a review)
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