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CAS RN: 145525-41-3 | 产品编码: M3177
Mitiglinide Calcium
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Chelometric Titration) | min. 97.0 % |
| Specific rotation [a]20/D | +5.0 to +9.0 deg(C=1, MeOH(calcd.on anh.substance)) |
| Water | 4.5 to 6.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 185 °C |
| 比旋光度 [α]D | 5.5° (C=1,MeOH) |
GHS
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Mitiglinide Calcium: A Fast-Acting Insulin-Releasing Agent
Mitiglinide calcium (KAD-1229; s 21403) is a glitinide class non-sulfonylurea insulinotropic agent with rapid onset. More rapidly than that of sulfonylurea antidiabetics, mitiglinide inhibits ATP-gated K+ channels and thereby causes depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. For your reference, [O0471] is a synthetic intermediate of mitiglinide. (The product is for research purpose only.)
References
- Novel rapid- and short-acting hypoglycemic agent, a calcium(2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) that acts on the sulfonylurea receptor: comparison of effects between KAD-1229 and gliclazide.
- The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.
- Effects of mitiglinide (s 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel
- Mitiglinide: a novel agent for the treatment of type 2 diabetes mellitus (a review)
- Simple, sensitive, and rapid LC-ESI-MS method for quantification of mitiglinide in human urine
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