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CAS RN: 578-76-7 | 产品编码: M3490
7-Methylguanine
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| 产品编码 | M3490 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__6H__7N__5O = 165.16 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| 包装和容器
|
250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 578-76-7 |
| Reaxys-RN | 20706740 |
| MDL编号 | MFCD00038003 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | MF8464000 |
运输信息
| HS编码* | 2933.59-000 |
应用
7-Methylguanine: A Metabolite of DNA Methylation
7-Methylguanine (m7Gua) is a metabolite of DNA methylation. There are reports that it has been used as a biomarker for DNA methylation which is one of the most common and most studied epigenetic processes.1-3) For your reference, the 7-methylguanine ribonucleoside is called 7-methylguanosine [M3465]. However, the 7-methylguanine base is not involved in the synthesis of nucleotides and not incorporated directly into nucleic acids.4) (The product is for research purpose only.)
References
- 1) Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosine
- 2) Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: effect modification by mu class glutathione-S-transferases
- 3) Rapid and sensitive quantification of urinary N7-methylguanine by isotope-dilution liquid chromatography/electrospray ionization tandem mass spectrometry with on-line solid-phase extraction
- 4) O6-methylguanine, but not N7-methylguanine or N3-methyladenine, induces gene mutations, sister-chromatid exchanges and chromosomal aberrations in Chinese hamster cells
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