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CAS RN: 826-39-1 | 产品编码: M3503
Mecamylamine Hydrochloride
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| 产品编码 | M3503 |
| 纯度/分析方法 | >98.0%(T) |
| 分子式/分子量 | C__1__1H__2__1N·HCl = 203.75 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,湿气 (吸湿) |
| CAS RN | 826-39-1 |
| Reaxys-RN | 7097642 |
| MDL编号 | MFCD00151462 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Purity(Precipitation Titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | RB6900000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2921.30-000 |
应用
Mecamylamine Hydrochloride: A Nicotinic Acetylcholine Receptors (nAChRs) Antagonist
Mecamylamine hydrochloride is a non-selective, non-competitive antagonist of the nicotinic acetylcholine receptors (nAChRs). It was developed as an antihypertensive agent in the 1950s, but is rarely used today for hypertension because of its widespread ganglionic side effects, and is more often now as a neuro research tool. Mecamylamine easily traverses the blood-brain barrier to reach the central nervous system (CNS), where it acts as a nicotinic acetylcholine receptor antagonist.1-5) This effect is thought to be due to antagonist effects at the α4β2 nicotinic receptors in the brain.4) Recently, it is expected to be used as an agent in treating CNS disorders, including nicotine and alcohol addiction in clinical.5) (The product is for research purpose only.)
References
- 1) Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes
- 2) Blockade of nicotine self-administration with nicotinic antagonists in rats
- 3) Nicotinic acetylcholine receptors as targets for antidepressants (a review)
- 4) TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity
- 5) Potential therapeutic uses of mecamylamine and its stereoisomers
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